Late-type allergy to the X-ray contrast medium Solutrast (R) (iopamidol)

In the past few years, there have been an increasing number of publications on delayed intolerance reactions, including rashes, following the use of X -ray contrast media. We report a patient in whom infiltrated erythema of th e face and generalized maculopapular rashes occurred on 2 occasions, within 1 day, following the use of the X-ray contrast medium Solutrast(R) (iopami dol) for coronary angiography. The allergological investigations for clarif ication included prick tests and patch tests using a series of contrast med ia, as well as individual intravenous provocation tests. We found the cause to be a late-type allergy to the active substance iopamidol contained in t he contrast medium Solutrast(R). We found a concomitant cross-reactivity to the contrast media iopromid and iomeprol. All 3 contrast media represent t he monomeric, non-ionic type.