Significant progress has been made in our understanding of the neural subst
rates of emotion and its disorders. Neuroimaging methods have been used to
characterize the circuitry underlying disorders of emotion. Particular emph
asis has been placed on the prefrontal cortex, anterior cingulate, parietal
cortex, and the amygdala as critical components of the circuitry that may
be dysfunctional in both depression and anxiety.