Antifungal resistance in non-albicans Candida species

Non-Candida albicans species have emerged as important bloodstream pathogen s. They tend to have decreased susceptibility to antifungal agents in vitro and cause infections associated with high morbidity and mortality. Flucona zole resistance can emerge in any Candida spp., but is most commonly seen w ith Candida krusei, for which resistance is universal, and with Candida gla brata. Amphotericin B resistance has also been increasingly reported, most notably in isolates of Candida lusitaniae and Candida guilliermondii. Effor ts are underway to correlate in-vitro antifungal susceptibility of individu al Candida isolates with response to therapy of patients with candidemia. F uture advances in this field might allow physicians to identify Candida iso lates resistant to specific antifungal agents and thereby tailor therapy of candidemia.