Effect of prostacyclin on gastric mucosal RNA-content in the rat

Authors
Balint, GA
Citation
Ga. Balint, Effect of prostacyclin on gastric mucosal RNA-content in the rat, EXP TOX PAT, 51(3), 1999, pp. 207-208
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
ISSN journal
09402993 → ACNP
Volume
51
Issue
3
Year of publication
1999
Pages
207 - 208
Database
ISI
SICI code
0940-2993(199905)51:3<207:EOPOGM>2.0.ZU;2-O
Abstract
We investigated changes in gastric (antral and fundic) mucosal RNA contents in single-dose and in long-term (10 weeks) treatment of rats with receivin g oral graded doses of prostacyclin. Long-term application of prostacyclin evoked no significant changes, while in the single-dose experiments there w as a dose-dependent elevation in RNA-content in both parts of the gastric m ucosa. The results are interpreted as convincing signs of the gastro-protec tive effect of prostacyclin.