T. Grushko et al., Genetic evidence that Notch affects independently the development of machrochaeta and wing venation in Drosophila melanogaster, HEREDITAS, 129(3), 1998, pp. 251-257
Temperature sensitive experiments on the interaction of Abruptex mutations
of the Notch locus and Enhancer of split indicate that the effect of temper
ature on the development of macrochaeta and wing venation is different. Thi
s suggest that Notch affects the development of macrochaeta and wing venati
on in different and independent ways being in accordance with the propositi
on that the signal pathway from the Notch receptor at the cell membrane to
Enhancer of split complex in the nucleus is different in the case of the de
velopment of macrochaeta and wing venation. The Abruptex mutations as gain-
of-function mutations of the Notch locus cannot rescue the Enhancer of spli
t phenotype.