Syndrome X is likely to be caused by a dysfunction of small coronary arteri
es. Several authors suggested that an increased adrenergic activity could b
e involved in the pathogenesis of syndrome X, but studies investigating thi
s topic by indirect methods led to conflicting results.
We directly investigated cardiac sympathetic nerve function in syndrome X b
y myocardial radionuclide studies with I-123-metaiodobenzylguanidine (MIBG)
. Twelve syndrome X patients and 10 healthy controls were enrolled in the s
tudy.
Cardiac MIBG uptake was assessed calculating the heart/mediastinum (HIM) ra
tio and a semiquantitative MIBG uptake score. Cardiac MIBG images were norm
al in all but 1 of controls (10%). Conversely, abnormalities in cardiac MIB
G uptake were found in 9 syndrome X patients (75%, p < 0.01). In 5 patients
the heart was totally or almost totally invisible on radionuclide MIBG ima
ges, while regional defects were found in other 4 patients. The HIM ratio w
as lower and cardiac MIBG uptake score strikingly higher in syndrome X pati
ents. At 3 hours the H/M ratio was 1.70 +/- 0.6 in patients and 2.19 +/- 0.
3 in controls (p = 0.03), while MIBG uptake score was 36.7 +/- 31 and 4.0 /- 2.5 (p = 0.003) in the 4 groups, respectively. There were no differences
between patients and controls in lung and salivary MIBG uptake. Reversible
perfusion defects on stress thallium scintigraphy were found in 5 syndrome
X patients (45%), all of whom also had abnormal MIBG scintigrams, while al
l 3 patients with normal MIBG scintigraphy also had normal thallium images.
Thus, the function of efferent cardiac adrenergic nerve fibers is strongly
impaired in the majority (i. e., 75%) of syndrome X patients. This abnormal
function likely contributes significantly to the pathophysiologic and clin
ical features of syndrome X. We speculate that also the increased perceptio
n of cardiac pain reported in these patients could be an expression of the
abnormal function of cardiac nerves, reflecting alterations of afferent noc
iceptive cardiac nerve fibers, as the abnormalities in MIBG uptake reflect
alterations of efferent cardiac adrenergic nerve fibers.