The use of clozapine in an individual with moderate intellectual disability, aggressive behaviour and resistant psychosis

The case of a 32 year old man with moderate intellectual disability, severe behavioural problems and psychotic symptoms is described. Having tried var ious traditional antipsychotics he was commenced on clozapine with a marked improvement in symptoms. Clozapine is a useful drug for the treatment of s chizophrenia in the intellectually disabled who are refractory to the conve ntional antipsychotics. It improves aggressive and self-injurious behaviour which may be in addition to its antipsychotic effect.