We report the case of a 74-year-old woman who had three episodes of aseptic
meningitis in a period of 20 years. These episodes always occurred a few h
ours after the assumption of a non-steroidal anti-inflammatory drug (NSAID)
per os. Nevertheless, the pharmacological anamnesis did not receive proper
attention, neither the first nor the second time, and the meningeal syndro
me with aseptic liquor was attributed to a viral aggression. However, when
the third episode occurred, due to the strict time correlation between the
assumption of the drug and the occurrence of symptoms, both the results of
the liquoral analysis and the anamnestic records allowed recognition of ibu
profen as the cause of acute meningitis.