IPD-1151T (suplatast tosilate) inhibits interleukin (IL)-13 release but not IL-4 release from basophils

Authors
Shichijo, M Shimizu, Y Hiramatsu, K Togawa, M Inagaki, N Takagi, K Nagai, H
Citation
M. Shichijo et al., IPD-1151T (suplatast tosilate) inhibits interleukin (IL)-13 release but not IL-4 release from basophils, JPN J PHARM, 79(4), 1999, pp. 501-504
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
79
Issue
4
Year of publication
1999
Pages
501 - 504
Database
ISI
SICI code
0021-5198(199904)79:4<501:I(TII(>2.0.ZU;2-2
Abstract
The effect of suplatast tosilate (IPD-1151T), which is known to suppress in terleukin (IL)-4 release from T cells, on the release of IL-4 and IL-13 fro m human peripheral basophils was investigated. Basophils were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T clearly inhibited t he antigen-induced release of IL-13 but not IL-4. These results suggest tha t IPD-1151T possesses different activity for the regulation of cytokine rel ease in basophils and T cells.