Synthesis and reactivity of 3-alkylthio-5-cyanomethyl-4-phenyl-1,2,4-triazoles

Authors
Mekheimer, RA Shaker, RM
Citation
Ra. Mekheimer et Rm. Shaker, Synthesis and reactivity of 3-alkylthio-5-cyanomethyl-4-phenyl-1,2,4-triazoles, J CHEM R-S, (2), 1999, pp. 76-77A
Citations number
19
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
2
Year of publication
1999
Pages
76 - 77A
Database
ISI
SICI code
0308-2342(199902):2<76:SARO3>2.0.ZU;2-Z
Abstract
Phenyl isothiocyanate reacts with 2-cyanoacetohydrazide (1) to yield the co rresponding 1-cyanoacetyl-4-phenylthiosemicarbazide (3), via acid hydrolysi s of the intermediate 2 whereas cyclization of 3 gave the 1,2,4-triazoles 4 , 1,3,4-thiadiazoles 7 and 1,3,4-thiadiazine-5-ones 9; compound 4a was reac ted with phenyl isothiocyanate, dicyandiamide, sulfanylacetic acid and benz aldehyde to afford 11, 13, 14 and 15, respectively.