Chitosan derivatives as chiral selectors bonded on allyl silica gel: preparation, characterisation and study of the resulting high-performance liquidchromatography chiral stationary phases

Several mixed 10-undecenoyl/phenylaminocarbonyl or benzoyl derivatives of c hitosan, differently substituted in the aromatic ring, were prepared, chara cterized and immobilized on allylsilica gel. The resulting high-performance liquid chromatography (HPLC) chiral supports were tested chromatographical ly. The influence of the starting polysaccharidic material, as well as that of the solvents used as mobile phase modifiers, on the preparation and per formance of the resulting chiral stationary phases (CSPs) is discussed. (C) 1999 Elsevier Science B.V. All rights reserved.