FLECAINIDE-SELECTIVE MEMBRANE ELECTRODES

Two liquid membrane electrodes were prepared based on ion-pair complex es of flecainide with dipicrylamine (I) and lauryl sulphate (II). The utilization range is 10(-2)-10(-5) M flecainide solution for both elec trodes, with a slope of 51.3 mV/decade (I) and 54.0 mV/decade (II), re spectively. The detection limits are 8.3 x 10(-7) M (I) and 1 x 10(-9) M (II) respectively. Electrodes showed fast response, good reproducib ility and stability. The compression excipients (magnesium stearate, m icrocrystalline cellulose and starch) do not interfere. Electrodes can be used to lest the uniformity of flecainide pharmaceutical tablets ( Tambocor tablets), as well as to determine the purity of flecainide ac etate-raw material. They also can be used to determine the dissolution profile of Tambocor tablets, the dissolution model and the apparent f irst order rate constants for disintegration and dissolution processes .