Cytotoxic polyacetylenes from the marine sponge Petrosia sp.

Three C-46 (1--3) and three C-30 (4-6) polyacetylenic alcohols with cytotox ic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was ident ified as the stereoisomer of petrocortyne A, the structures of compounds 2- 5 have not been previously reported and were established by spectral method s. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's me thod.