Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp.

Authors
Chen, CY Shen, YC Chen, YJ Sheu, JH Duh, CY
Citation
Cy. Chen et al., Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp., J NAT PROD, 62(4), 1999, pp. 573-576
Citations number
10
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
4
Year of publication
1999
Pages
573 - 576
Database
ISI
SICI code
0163-3864(199904)62:4<573:BSFATM>2.0.ZU;2-E
Abstract
Five new sesquiterpenes, parahigginols A-D (1-4) and parahigginic acid (5), have been isolated from a Taiwanese marine sponge Parahigginsia sp. The st ructural assignments of the new compounds were based on their spectral data , including 1D and 2D NMR. Biological studies revealed that compounds 2-5 e xhibited cytotoxicity against murine P-388 and human KB16, A549, and HT-29 tumor cells.