Malayenolides A-D, novel diterpenes from the Indonesian sea pen Veretillummalayense

Malayenolides A-D (1-4), four new briarane diterpenes, were isolated from t he sea pen Veretillum malayense collected in Indonesia. The new diterpenes possess benzoate and senecioate substitutents, both of which are rare among marine natural products. The structures of the new compounds were determin ed from spectral data. Compounds 1-4 are toxic to brine shrimp.