10 '-hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis

Authors
Frederich, M Tits, M Hayette, MP Brandt, V Penelle, J DeMol, P Llabres, G Angenot, L
Citation
M. Frederich et al., 10 '-hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis, J NAT PROD, 62(4), 1999, pp. 619-621
Citations number
19
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
4
Year of publication
1999
Pages
619 - 621
Database
ISI
SICI code
0163-3864(199904)62:4<619:1'ANAB>2.0.ZU;2-Q
Abstract
Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), whic h was identified by detailed spectroscopic methods. Compound 1 was moderate ly active against two strains of Plasmodium falciparum in vitro.