New bis(indole) alkaloids of the topsentin class from the sponge Spongosorites genitrix

Four bis(indole) alkaloids of the topsentin class, including two new bromin ated compounds (1 and 2), have been isolated from the sponge Spongosorites genitrix collected from Jaeju Island, Korea. The structures of the novel co mpounds were determined by spectroscopic methods. These compounds exhibited moderate cytotoxicity against a human leukemia cell-line (K-562).