Jrle. Silva et al., Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus, MEDIAT INFL, 8(1), 1999, pp. 17-23
WE examined the effect of the immunosuppressive agent, tacrolimus (FK506),
on antigen-induced bronchial hyperreactivity to acetylcholine and leukocyte
infiltration into the airways of ovalbumin-challenged guinea-pigs, Subcuta
neous injection of 0.5 mg/kg of FK506, 1 h before and 5 h after intra-nasal
antigen challenge prevented bronchial hyperreactivity to aerosolized acety
lcholine, eosinophilia in bronchoalveolar lavage (BAL) fluid and bronchial
tissue and the invasion of the bronchial wall by CD4(+) T-lymphocytes, FK50
6 also suppressed ovalbumin-induced increase in the number of leukocytes ad
hering to the pulmonary vascular endothelium and expressing alpha 4-integri
ns. Inhibition by FK506 of antigen-induced bronchial hyperreactivity in sen
sitized guinea-pigs may thus relate to its ability to prevent the emergence
of important inflammatory components of airway inflammation, such as eosin
ophil accumulation, as well as CD4(+) T-lymphocyte infiltration into the br
onchial tissue.