Biophysical shunt theory for neuropsychopathology: pentaphasic lipid-induced model for schizophrenia

We propose a five-phase model for schizophrenia: (A) Imperfect diet-induced fatty acid combinations are mobilized from reservoirs during stress exposu re into the bloodstream; (B) Increased brain-blood barrier permeability, wi th a further penetration of fat into the brain matter; (C) Rearrangement in the regional neuronal membrane fatty acids with a further physical compres sion of the adjacent membrane protein structures causing conformational alt erations; (D) Cytokines generate further physical changes, impairing single - or multi-dispersed ion channels placed on the same neuron; (E) ion channe ls are blocked, with a subsequent biophysical ion shunt-to-ion flow propaga tion, which results in neuronal misfiring and the appearance of schizophren ic signs and symptoms.