Solution-phase combinatorial chemistry

The use of solution phase techniques has been explored as an alternative to solid-phase chemistry approaches for the preparation of arrays of compound s in the drug discovery process. Solution-phase work is free from some of t he constraints of solid-phase approaches but has disadvantages with respect to purification. This article will also illustrate some of the advances ma de in recent years in solution phase array chemistry including using suppor ted reagents and simple extractive protocols for the effective preparation of high quality samples.