The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues

Authors
Suopanki, J Tyynela, J Baumann, M Haltia, M
Citation
J. Suopanki et al., The expression of palmitoyl-protein thioesterase is developmentally regulated in neural tissues but not in nonneural tissues, MOL GEN MET, 66(4), 1999, pp. 290-293
Citations number
13
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND METABOLISM
ISSN journal
10967192 → ACNP
Volume
66
Issue
4
Year of publication
1999
Pages
290 - 293
Database
ISI
SICI code
1096-7192(199904)66:4<290:TEOPTI>2.0.ZU;2-7
Abstract
Mutations in a palmitoyl-protein thioesterase (PPT) gene cause infantile ne uronal ceroid lipofuscinosis (INCL). INCL is characterized by an extreme an d selective neuronal loss in cerebral cortex and retina. Using reverse tran scriptase PCR we show that PPT expression is developmentally regulated in r at brain and eyes but not in spleen. The changes in the expression coincide with developmental events in the brain. These data indicate that PPT has a n important role in the development of the CNS. (C) 1999 Academic Press.