Wholemount preparations of oocytes from fetal bovine ovaries were exam
ined in an attempt to study the incidence and type of chromosomes invo
lved in pairing irregularities during different stages of early ovaria
n differentiation. Synaptonemal complexes exhibiting pairing irregular
ities were noted in meiocytes of all age groups. However, asynapsis an
d partial synapsis were more frequently noted in X chromosomes at the
onset of meiosis in fetal bovine ovaries while the frequencies of simi
lar errors in autosomes were relatively low and remained unchanged in
the age groups included in this study. The significance and mechanisms
of X chromosome asynapsis in excess of that expected on the basis of
numerical ratio of the X to the bovine meiotic complement, are not kno
wn at present. We hypothesize that changes in the transcriptional stat
us involving activation, inactivation, and reactivation of the X chrom
osomes during embryonic and ovarian differentiation on the conceptus,
in addition to the inactivation undergone by the paternal X chromosome
prior to fertilization, could be a factor rendering them susceptible
to structural changes which, in turn may increase the incidence of sex
chromosome asynapsis at the onset of meiosis in female fetuses.