Biologically active compounds from Ozothamnus leptophyllus

A crude extract from a New Zealand native plant, Ozothamnus leptophyllus, w as shown to possess antifungal activity. Flavonoids, mainly chalcones in th e leaf exudate, were isolated, some of which possessed antiviral as well as antifungal activity. These flavanoids are excreted by glandular trichomes and form quasi-crystalline deposits on the abaxial side of the leaves. 2',4 ',6'-Trihydroxychalcone was found to be active against both Polio virus (Pf izer vaccine strain) and Herpes simplex type 1 (ATCC VR 733); it was also r esponsible for antidermatophytic activity against Trichophyton mentagrophyt es. 2',4'-Dihydroxy-4'-methoxydihydrochalcone was also active against both viruses.