Nicorandil, a potassium channel opener, abolished Torsades de Pointes in apatient with complete atrioventricular block

Authors
Watanabe, O Okumura, T Takeda, H Nakamura, W Segawa, K Ito, H Yoshimoto, N
Citation
O. Watanabe et al., Nicorandil, a potassium channel opener, abolished Torsades de Pointes in apatient with complete atrioventricular block, PACE, 22(4), 1999, pp. 686-688
Citations number
10
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
ISSN journal
01478389 → ACNP
Volume
22
Issue
4
Year of publication
1999
Part
1
Pages
686 - 688
Database
ISI
SICI code
0147-8389(199904)22:4<686:NAPCOA>2.0.ZU;2-I
Abstract
TdP is a serious complication of AV block. We report a case of complete AV block with QT prolongation who had bouts of TdP resistant to lidocaine and isoproterenol. Temporary pacing could not be performed, because insertion o f a pacing lead triggered TdP that deteriorated into ventricular fibrillati on. Nicorondil, a potassium channel opener; shortened the QT interval and a bolished TdP. This may suggest that potassium channel opening drugs are cli nically effective against TdP associated with bradycardia-dependent QT prol ongation.