Decisions to undertake fetal therapy involve a complex assessment of the be
st interests of the fetus and a pregnant woman's interest in her own health
and freedom from unwanted invasion of her body. Pregnant women almost alwa
ys accept a recommendation for fetal therapy that is approached collaborati
vely, especially if the therapy is of proven efficacy and has a low materna
l risk. Fetal therapy of unproven efficacy should only be undertaken as par
t of an approved research protocol. In recommending fetal therapy of proven
efficacy, physicians should respect maternal choice and assessment of risk
. Under limited circumstances when fetal therapy would be effective in prev
enting irrevocable and substantial fetal harm with negligible risk to the h
ealth and well-being of the pregnant woman, should the pregnant woman be op
posed to the intervention, physicians should engage in a process of communi
cation and conflict resolution that may require consultation from an ethics
committee and, in rare cases, require judicial review. A physician should
never intervene without the woman's explicit consent before judicial review
.