Undesirable blood pressure changes under naturalistic treatment with moclobemide, a reversible MAO-A inhibitor - Results of the drug utilization observation studies

Blood pressure decrease, associated with postural hypotension, as well as s pontaneous hypertension are considered to be typical side-effects of conven tional, irreversible and nonselective MAO (A+B) inhibitors, The new generat ion of reversible MAO-A inhibitors is, however, expected to have negligible cardiovascular effects and low propensity to induce either blood pressure increases or decreases. But, the true incidence of such changes is largely unknown since observation studies, specifically assessing the frequency of blood pressure changes, in unselected population of patients treated in the practice, are lacking.