Ex-chiral pool synthesis and pharmacological aspects of 3-pyrrolidinylisoxazoles

Authors
Thomas, C Ohnmacht, U Zahn, K Mohr, K Gmeiner, P
Citation
C. Thomas et al., Ex-chiral pool synthesis and pharmacological aspects of 3-pyrrolidinylisoxazoles, PHARMAZIE, 54(4), 1999, pp. 248-250
Citations number
23
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
4
Year of publication
1999
Pages
248 - 250
Database
ISI
SICI code
0031-7144(199904)54:4<248:EPSAPA>2.0.ZU;2-V
Abstract
Employing the dopamine autoreceptor agonist (-)-3-PPP (3) as well as the ch olinergic receptor ligands 4 and 5 as lead compounds the 3-pyrrolidinylisox azoles 2a,b as well as its optical antipodes ent-2a,b were synthesized from (R)-aspartic acid (6) and (S)-aspartic acid (ent-6), respectively. Pharmac ological properties of the target compounds were evaluated employing dopami ne D2 receptor binding studies and functional experiments on muscarinic M2 receptors.