Synthesis of new 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)-amino] substituted 4(3H)-quinazolinone derivatives with antineoplastic activity

Authors
Raffa, D Daidone, G Schillaci, D Maggio, B Plescia, F
Citation
D. Raffa et al., Synthesis of new 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)-amino] substituted 4(3H)-quinazolinone derivatives with antineoplastic activity, PHARMAZIE, 54(4), 1999, pp. 251-254
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
4
Year of publication
1999
Pages
251 - 254
Database
ISI
SICI code
0031-7144(199904)54:4<251:SON3O3>2.0.ZU;2-Z
Abstract
A novel series of 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl) amino] substituted 4(3H)-quinazolinone derivatives was synthesized. The com pounds were tested for their antineoplastic activity in vitro against Raji (human Burkitt limphoma), K-562 (human chronic myelogeneous leukemia) and U 937 (human histiocytic limphoma) cell lines. The most active quinazolinones showed IC50 values in the range 16-30 mu M.