Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity bydiosmin

Authors
Melzig, MF Loose, R
Citation
Mf. Melzig et R. Loose, Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity bydiosmin, PHARMAZIE, 54(4), 1999, pp. 298-299
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
54
Issue
4
Year of publication
1999
Pages
298 - 299
Database
ISI
SICI code
0031-7144(199904)54:4<298:IOL(EC>2.0.ZU;2-N
Abstract
The cytotoxic effect of lipopolysaccharide (LPS) on cultivated bovine aorti c endothelial cells was determined. This LPS-induced cytotoxicity was atten uated by diosmin, That means, the IC50-value of LPS in the combination with 8 mu mol/l diosmin was shifted from 31 to 70 ng/ml in a concentration depe ndent manner. As a hypothesis it was suggested, that the inhibition of LPS- induced cytotoxicity in bovine aortic endothelial cell cultures by diosmin could be probably mediated via inhibition of tyrosine kinases.