A series of semicarbazones and thiosemicarbazones were synthesized and eval
uated for anti-convulsant activity. Some compounds provided significant pro
tection against Maximal Electroshock (MES) and subcutaneous strychnine indu
ced seizures. Compound 1 was the most active in the series with activity in
a dose of 30 mg/kg in the strychnine seizure pattern test and an ED50 of 1
0 mg/kg in the MES test. Hence it could serve as a prototype molecule for f
uture development. Also compounds with a p-nitrophenyl substitution in plac
e of the amino hydrogen of semicarbazone moiety showed activity in a dose o
f 30 mg/kg and an ED50 of 83 mg/kg in the MES test.