Fetal trisomy 10 mosaicism: Ultrasound, cytogenetic and morphologic findings in early pregnancy

We report the ultrasound, cytogenetic and morphologic findings in a case of trisomy 10 mosaicism prenatally detected by chorionic villus sampling (CVS ). CVS sampling was carried out at the 13th week of gestation because of ul trasound diagnosis of hydrops fetalis and hygroma colli. Trisomy 10 mosaici sm was diagnosed in cells from the cytotrophoblast (short-term culture) and the chorionic villus core (long-term culture). Fetal mosaicism was confirm ed after termination of pregnancy in umbilical cord cells, placenta and fet al skin fibroblasts. Copyright (C) 1999 John Wiley & Sons, Ltd.