A comparison of the efficacy of long-acting beta(2)-agonists: eformoterol via Turbohaler (R) and salmeterol via pressurized metered dose inhaler or Accuhaler (R), in mild to moderate asthmatics
Lm. Campbell et al., A comparison of the efficacy of long-acting beta(2)-agonists: eformoterol via Turbohaler (R) and salmeterol via pressurized metered dose inhaler or Accuhaler (R), in mild to moderate asthmatics, RESP MED, 93(4), 1999, pp. 236-244
Four hundred and sixty nine patients were randomized to receive either 12 m
u g bd of eformoterol (Oxis(R), Astra Pharmaceuticals Ltd., Kings Langley,
U.K.) delivered via Turbohaler(R) or 50 mu g bd salmeterol (Serevent(R) Gla
xo-Wellcome Ltd., Uxbridge, U.K.) via either the Accuhaler(R) (Glaxo-Wellco
me Ltd.) or pressurized metered dose inhaler (pMDI, Glaxo-Wellcome Ltd.) fo
r 8 weeks. This was followed by a 4-week cross-over period when patients wh
o had received salmeterol in the previous 8 weeks were given eformoterol an
d patients who had received eformoterol were given either salmeterol via th
e Accuhaler(R) or pMDI to assess patient device and treatment preference.
For the primary efficacy variable, the increase in peak expiratory flow (PE
F) rate from run-in to 8 weeks, similar significant improvements were seen
in all three treatment groups, Eformoterol Turbohaler(R) (FT) achieved a gr
eater increase in morning PEF than salmeterol Accuhaler(R) (SA) from random
isation to 4 weeks; the increase shown in the eformoterol Turbohaler(R) gro
up was 28.91 min(-1) compared to 19.91 min(-1) for the salmeterol Accuhaler
(R) group. The addition of eformoterol Turbohaler(R) 12 mu g bd, to patient
s' existing asthma therapy was found to have a significantly more beneficia
l effect on the severity of patients' daytime asthma symptoms than had salm
eterol Accuhaler(R) 50 mu g bd (P=0.014). Eformoterol Turbohaler(R) reduced
the severity of daytime asthma symptoms by 42% after only 4 weeks of treat
ment. The patients in the eformoterol Turbohaler(R) treated group experienc
ed a higher percentage of days when they were symptom-free and did not use
their short-acting bronchodilator to relieve symptoms (32.8, 24.1 and 28.0%
in the FT, SA and SM groups, respectively). At 8 weeks there were no signi
ficant differences in any of these variables between the three groups,
Patients in all the treatment groups gained an additional 1-1.5 nights undi
sturbed by asthma per week. The changes in sleep disturbance were not signi
ficantly different between the three treatment groups.
In addition to the therapeutic benefits provided by eformoterol Turbohaler(
R) the device (Turbohaler";) was the significant preference of patients giv
en both Turbohaler(R) and pMDI (P=0.0168) and was also considered to be sig
nificantly more convenient to carry around than the Accuhaler(R) (P<0.0001)
. No other differences were found between the three devices,
The results of this study demonstrate that the addition of a long-acting B-
2-agonist is an effective tool for achieving the goals of asthma treatment.
Eformoterol via the Turbohaler(R) is at least as effective as salmeterol v
ia either the Accuhaler(R) or the pMDI in achieving these goals.