The advent of high-T-c superconductors gave great impetus to the developmen
t of thin-film superconducting quantum interference devices (SQUIDs) for op
eration at temperatures up to the boiling point of liquid nitrogen, 77 K. T
he spectral density of the white flux noise can be calculated analytically
for rf SQUIDs and by computer simulation for de SQUIDs; however, observed n
oise spectral densities are typically an order of magnitude higher. Low-fre
quency lif noise from thermally activated vortex motion is a much bigger is
sue in high-T-c SQUIDs at 77 K than in low-T-c SQUIDs because of the low fl
ux-pinning energies in high-T-c superconductors. The magnitude of the noise
depends strongly on the quality of the thin films, and much effort has bee
n expended to improve techniques for depositing YBa2Cu3O7-x (YBCO) on latti
ce-matched single-crystal substrates. Substantial effort has also been inve
sted in the development of new types of Josephson junctions, of which grain
-boundary junctions are the most widely used in SQUIDs. Appropriate electro
nic read-out schemes largely eliminate lif noise from fluctuations in the j
unction critical current in both rf and dc SQUIDs. Typical levels of white
flux noise are a few mu Phi(0) Hz(-1/2) (Phi(0) is the flux quantum). Magne
tometers-consisting of a superconducting flux transformer coupled to a SQUI
D-achieve a white magnetic-field noise as low as 10 fT Hz(-1/)2, increasing
to typically 30 fT Hz(-1/2) at 1 Hz. When these devices are operated in an
unshielded environment, it is important to minimize the motion of trapped
vortices and induced supercurrents, which can greatly increase the 1/f nois
e. The ambient noise is far greater than the intrinsic noise of the devices
, but can be substantially reduced by various gradiometer configurations. T
here is now considerable effort to apply high-T-c SQUIDs in magnetocardiolo
gy, nondestructive evaluation, microscopy, and geophysics. [S0034-6861(99)0
0403-1].