The usefulness of the somatosensory evoked potentials of the pudendal nerve in diagnosis of probable multiple sclerosis

Study design: The aim of the study was to evaluate the sensitivity of pSEP in patients affected by probable MS. Objectives: Bladder dysfunction is the presenting symptom in 2% of patients affected by multiple sclerosis (MS) and may be present in up to 78% of the m. Abnormalities of somatosensory evoked potentials of the pudendal nerve ( pSEP) have been found by many authors in patients affected by clinically de fined MS, but little is known of diagnostic reliability of pSEP in early st age of MS. Methods: Sixteen patients, eleven females and five males, aged between 18 a nd 45 years old (mean age 28.9), affected by clinically probable MS, were s tudied. Six of them reported retention or urge incontinence. pSEP with P1 ( P40) scalp wave was analyzed. All patients also underwent visual evoked pot entials (VEP), SEP of median and tibial nerves (mSEP, tSEP), brainstem acou stic evoked potentials (BAEPs), MRI of the brain and cerebrospinal fluid (C SF) evaluation. Urodynamic study with simultaneous measurement of intravesi cal, intraurethral and abdominal pressures with external sphincter electrom yography was performed. Results: Abnormalities of the evoked potentials were found in all patients. Abnormalities of the pSEP were observed in all the symptomatic cases and i n eight of the remaining ten patients; ten showed no responses from the sca lp and four showed P1 increased latency. Urodynamic abnormalities were foun d in 12 patients and MRI showed demyelinating lesions in 13 patients and ol igoclonal bands were found in eight of them. Conclusion: pSEP can be worthwhile as part of the initial diagnostic evalua tion in patients affected by MS. It provides information of diagnostic rele vance and plays a role in screening patients for urodynamic testing, which, however, is more specific for detecting urethrovesical dysfunctions and pr eventing urological complications.