Reaction of mercaptoacetate and halides containing activated methylenes with thiocarbamoylimidates: A novel approach to the synthesis of aminothiazole derivatives

The reaction of N-thiocarbamoylimidates (1) under bar with methyl thioglyco late leads to the formation of 4-arylamino-5-methoxycarbonylthiazoles (2) u nder bar. The condensation of the same imidates (1) under bar on ethyl brom oacetate, benzyl bromide and chloroacetonitrile provides the corresponding 2-arylaminothiazoles (4) under bar.