Citation
J. Cossy et al., Approaches to a synthesis of alpha-kainic acid, TETRAHEDRON, 55(19), 1999, pp. 6153-6166
Citations number
42
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
55
Issue
19
Year of publication
1999
Pages
6153 - 6166
Database
ISI
SICI code
0040-4020(19990507)55:19<6153:ATASOA>2.0.ZU;2-I
Abstract
alpha-Kainic acid A, first isolated in 1953 from the marine alga Digenea si
mplex,(1) is the parent member of the kainoids displaying potent anthelmint
ic properties and neurotransmitting activity(2,3) in the central nervous sy
stem. Among these properties, the neuroexcitatory activity is attributed to
their trans C-2/C-3 : cis C-3/C-4 structure and the functionality at the C
-4 center beside the 2-carboxy and 3-carboxymethyl functionalities.