Synthetic studies toward ansatrienines: application of the Evans-Tishchenko reaction to chiral enones

Authors
Schoning, KU Hayashi, RK Powell, DR Kirschning, A
Citation
Ku. Schoning et al., Synthetic studies toward ansatrienines: application of the Evans-Tishchenko reaction to chiral enones, TETRAHEDR-A, 10(5), 1999, pp. 817-820
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
5
Year of publication
1999
Pages
817 - 820
Database
ISI
SICI code
0957-4166(19990312)10:5<817:SSTAAO>2.0.ZU;2-N
Abstract
Practical syntheses of the C9-C14 sterotriade 5 and the C1-C8 polyene unit 6 in ansatrienine A (mycotriene) (la), and other ansamycin antibiotics is d escribed. A key step for controlling the configuration of the stereogenic c enter at C13 involves the stereoselective reduction of enone 10 using the E vans-Tishchenko reaction. (C) 1999 Elsevier Science Ltd. All rights reserve d.