WILSONS-DISEASE

We describe a patient who had severe neurologic symptoms, psychiatric abnormalities, and secondary amenorrhea superimposed on a history of h emolytic anemia and micronodular cirrhosis attributed to hemochromatos is. The correct diagnosis of Wilson's disease was delayed until the ap pearance of Kayser-Fleischer rings and a low serum ceruloplasmin level . Appropriate treatment ameliorated symptoms, and maintenance therapy has been effective in retarding progression. It is essential to consid er Wilson's disease in patients with unexplained hepatic, neurologic, and psychiatric dysfunction, because appropriate early medical treatme nt can prevent further organ damage and reduce the risk of permanent d amage to the liver and brain.