A. Stenberg et al., DiHA dextran copolymer, a new biocompatible material for endoscopic treatment of stress incontinent women - Short term results, ACT OBST SC, 78(5), 1999, pp. 436-442
Background. This study was undertaken to investigate the safety and effect
of DiHA, dextranomers in hyaluronan, a new biocompatible material for endos
copic treatment of stress incontinence, and to further develop the injectio
n technique.
Methods. Twenty women aged 38 to 90 years with genuine stress incontinence
participated. Seventeen were followed for a minimum of 6 months after treat
ment and three for a minimum of 3 months. The DiHA implants were administre
red by transurethral endoscopically controlled submucosal injections under
local anesthesia. Safety was assessed mainly in terms of infection, need fo
r catheterization, residual urine and dysuria. The treatment efficacy was e
stimated objectively by a short-term pad test with standardized physical ex
ercise and a 48 h pad-test, 7 days, and 1, 3 and 6 months after treatment.
The patient's subjective experience of the effect was also studied.
Results. The implantation procedure was well accepted by the patients. Four
patients required catheterization due to voiding problems during the first
24 postoperative hours. One patient had urinary retention 14 days postoper
atively. No UTI or local infection was detected. Some patients had transien
t urgency. In 17 or 20 patients the treatment resulted in objective cure or
improvement.
Conclusion. This substance shows promising qualities for endoscopic treatme
nt of stress incontinence.