Quantitative estimation of the bitter taste intensity of oxyphenonium bromide reduced by cyclodextrins from electromotive force measurements

The bitter taste of oxyphenonium bromide, an antiacetylcholine drug, is sup pressed by cyclodextrins, The extent of the suppression can be predicted fr om the electromotive force measurements with an oxyphenonium bromide-select ive electrode. The relationship between the bitter taste intensity and the electromotive force holds true, regardless of the kind and concentration of natural and modified cyclodextrins. This result is explicable on the basis of the observation that both the bitter taste and the electric potential a re determined by the concentration of free oxyphenonium bromide. Some impli cations and limitations of the present approach are discussed.