Prognostic value of Lauren classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction

Background: The prognostic value of the Lauren classification and of c-erbB -2 oncogene overexpression has been described for gastric cancer. The aim o f this study was to investigate the clinical significance of these factors in adenocarcinoma of the esophagus and/or gastroesophageal junction (GEJ). Methods: Forty-one adenocarcinomas of the esophagus and/or GEJ were reviewe d for tumor stage, lymph node status, Lauren classification, and c-erbB-2 o verexpression, as assessed by immunohistochemical analysis. Results: According to the Lauren classification, tumors were classified as intestinal-, mixed-, or diffuse-type (54%, 32%, and 15%, respectively). Dif fuse-type tumors were associated with a significantly worse prognosis than were intestinal-type tumors (P = .018; log-rank test). The prognostic value of the Lauren classification was independent of stage (P = .048; Cox regre ssion model). Overexpression of c-erbB-2 was detected in 24% of the tumors and was present exclusively in intestinal-type tumors and in intestinal-typ e areas of mixed-type tumors. Ten of the 30 stage III/IV tumors (33%) were c-erbB-2-positive, whereas none of the II stage I/II tumors (0%) overexpres sed the oncogene product (P = .04; Fisher exact test). The prognostic value of c-erbB-2 overexpression was not independent of stage (P = .7; Cox regre ssion model). Conclusions: (1) The Lauren classification is an independent prognostic fac tor in adenocarcinoma of the esophagus and GEJ. (2) c-erbB-2 overexpression is Limited to (areas of) intestinal-type tumors, indicating that intestina l- and diffuse-type tumors differ oncogenetically. (3) c-erbB-2 overexpress ion is associated with the stage of disease, indicating that it is a late e vent during tumor progression.