Hemodynamic effects of methylprednisolone in patients undergoing cardiac operation and early extubation

Background. Whether or not methylprednisolone is beneficial during cardiac operation remains controversial. This study examines the effects of the dru g on complement activation and hemodynamics in patients undergoing cardiac operation and early extubation. Methods. Patients undergoing cardiac operation were randomized to receive e ither intravenous methylprednisolone (group MP) or intravenous placebo (gro up NS). Complement 3a (C3a) levels and hemodynamic parameters were obtained perioperatively. Extubation was accomplished at the earliest clinically ap propriate time. Results. Both groups exhibited equivalent increases in C3a levels after exp osure to bypass. Group MP exhibited increased cardiac index, decreased syst emic vascular resistance, and increased shunt flow when compared to group N S. More group MP patients required hemodynamic support and group MP patient s had prolonged extubation times. Conclusions. Methylprednisolone was unable to attenuate complement activati on and led to hemodynamic alterations (primarily vasodilation) that may hin der early extubation in patients after cardiac operations. (Ann Thorac Surg 1999;67:1006-11). (C) 1999 by The Society of Thoracic Surgeons.