Dopaminergic receptors are widespread throughout the central and peripheral
nervous systems, where they regulate a variety of physiological, behaviora
l, and endocrine functions. These receptors are also clinically important d
rug targets for the treatment of a number of disorders, such as Parkinson's
disease, schizophrenia, and hyperprolactinemia. To date, five different do
pamine receptor subtypes have been cloned and characterized. Many of these
subtypes are pharmacologically similar, making it difficult to selectively
stimulate or block a specific receptor subtype in vivo. Thus, the assignmen
t of various physiological or behavioral functions to specific dopamine rec
eptor subtypes using pharmacological tools is difficult. In view of this, a
number of investigators have-in order to elucidate functional roles-begun
to use highly selective genetic approaches to alter the expression of indiv
idual dopamine receptor subtypes in vivo. This review discusses recent stud
ies involving the use of genetic approaches for the study of dopaminergic r
eceptor function.