Prevalence and predictors of depressive symptoms in older premenopausal women - The Harvard Study of Mood and Cycles

Background: The Harvard Study of Moods and Cycles is a community-based coho rt study designed to evaluate the relationship between major depression and changes in menstrual and ovarian function. Methods: All women aged 36 to 44 years with a verifiable address from 7 Bos ton, Mass, metropolitan communities were selected from the Massachusetts To wn Books. A self-administered questionnaire assessed demographic characteri stics and menstrual history, depression history, and current depressive sym ptoms (Center for Epidemiologic Studies Depression Scale [CES-D]) in 4161 w omen. Results: We observed a score of 16 or more on the CES-D in 22.4% of women s urveyed, and 8.6% scored 25 or more. Widowed, divorced, or separated women were twice as likely as married women to have depression scores greater tha n 16 (95% confidence interval, 1.6-2.8), and smokers in the upper tertile o f pack-years were 1.9 times more likely to have CES-D scores of 16 or more (95% confidence interval, 1.5-2.3). Relative to nulliparous women, those wi th 1 or 2 children had a 30% lower risk of historic mood disorder, and thos e with 3 or more children had an even greater reduction in risk (odds ratio , 0.4; 95% confidence interval, 0.3-0.6). Menstrual cycle irregularities we re largely unassociated with current or past depression. However, 5 of 8 pr emenstrual symptoms were significantly associated with CES-D scores of 16 o r more. Conclusions: These findings corroborate the prevalence of depression report ed by other community-based studies, and also support a relationship betwee n depressive symptoms and marital status, cigarette smoking, nulliparity, a nd premenstrual symptoms.