Patients with substance abuse problems are common in general medical practi
ce and include people of all ages and socioeconomic groups. Initial diagnos
is and treatment of addiction problems are often done by the primary care p
ractitioner before referral to a specialist. This article provides informat
ion to help in recognition of addiction, guidelines for treatment of intoxi
cation and withdrawal of various drugs of abuse (such as opioids, sedative-
hypnotics, stimulants, hallucinogens, and volatile inhalants), and techniqu
es for brief intervention as well as long-term care of substance-abusing pa
tients. The physician can be a powerful influence for getting the patient t
o accept treatment, especially when the physician is empathic without being
judgmental. Addiction is a chronic disorder with remissions and relapses l
ike any other chronic disease, so exacerbations should not be seen as failu
res but as time to intensify treatment. Patients with substance abuse probl
ems can be frustrating to treat, but it can also be a rewarding experience
when a physician helps a substance-abusing patient return to normal and pro
ductive functioning in society.