The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site

Authors
Black, RM Harrison, JM Read, RW
Citation
Rm. Black et al., The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site, ARCH TOXIC, 73(2), 1999, pp. 123-126
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF TOXICOLOGY
ISSN journal
03405761 → ACNP
Volume
73
Issue
2
Year of publication
1999
Pages
123 - 126
Database
ISI
SICI code
0340-5761(199903)73:2<123:TIOSAS>2.0.ZU;2-O
Abstract
Incubation of both sarin and soman with human plasma has shown that binding occurs to a tyrosine residue. Similar binding occurs when sarin and soman are incubated with human serum albumin. This binding may provide an importa nt biological marker, which retains full structural information concerning the identity of the agent, in cases of allegations of chemical warfare use.