Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment

Authors
Inoue, T Tsui, J Wong, N Wong, SY Suzuki, F Kwok, YN
Citation
T. Inoue et al., Expression of glial cell line-derived neurotrophic factor and its mRNA in the nigrostriatal pathway following MPTP treatment, BRAIN RES, 826(2), 1999, pp. 306-308
Citations number
17
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
826
Issue
2
Year of publication
1999
Pages
306 - 308
Database
ISI
SICI code
0006-8993(19990501)826:2<306:EOGCLN>2.0.ZU;2-S
Abstract
Striatal glial cell line-derived neurotrophic factor (GDNF) mRNA levels in both young (2-month old) and old (11-month old) C57BL/6J mice were quantifi ed at 3, 7 and 21 days following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridi ne (MPTP) treatment. MPTP did not alter the expression of GDNF mRNA in thes e animals. Immunoreactive staining of GDNF in the substantia nigra and the striatum was also unchanged. in conclusion, MPTP-induced dopaminergic neuro toxicity does not elicit any changes in the expression of endogenous GDNF o r its mRNA in the adult mouse brain. (C) 1999 Elsevier Science B.V. All rig hts reserved.