Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick

Citation
T. Bungo et al., Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick, BRAIN RES, 826(2), 1999, pp. 313-316
Citations number
28
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
826
Issue
2
Year of publication
1999
Pages
313 - 316
Database
ISI
SICI code
0006-8993(19990501)826:2<313:IOFIBA>2.0.ZU;2-J
Abstract
To clarify noradrenergic systems on food intake of the neonatal chicks, we examined the effects of i.c.v injection of clonidine (CLON), an alpha(2)-re ceptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)-b eta-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON indu ced a narcoleptic response and reduced food intake, food intake at 30 min p ost-injection was enhanced by lower doses (25 and 50 ng) of CLON. Central a dministration of FA (25, 50 and 100 mu g) increased food intake in a dose-d ependent fashion. It is suggested that feeding behavior is stimulated by lo w levels of CLON and decreased by further production of norepinephrine (NE) , and FA may play the disturbance of sleeping and then enhance food intake. (C) 1999 Elsevier Science B.V. All rights reserved.