T. Bungo et al., Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick, BRAIN RES, 826(2), 1999, pp. 313-316
To clarify noradrenergic systems on food intake of the neonatal chicks, we
examined the effects of i.c.v injection of clonidine (CLON), an alpha(2)-re
ceptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)-b
eta-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON indu
ced a narcoleptic response and reduced food intake, food intake at 30 min p
ost-injection was enhanced by lower doses (25 and 50 ng) of CLON. Central a
dministration of FA (25, 50 and 100 mu g) increased food intake in a dose-d
ependent fashion. It is suggested that feeding behavior is stimulated by lo
w levels of CLON and decreased by further production of norepinephrine (NE)
, and FA may play the disturbance of sleeping and then enhance food intake.
(C) 1999 Elsevier Science B.V. All rights reserved.