Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2 '-deoxyadenosine

Authors
Van Den Neste, E Louviaux, I Michaux, JL Delannoy, A Michaux, L Hagemeijer, A Scheiff, JM Bosly, A Straetmans, N Ferrant, A
Citation
E. Van Den Neste et al., Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2 '-deoxyadenosine, BR J HAEM, 105(1), 1999, pp. 268-270
Citations number
12
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
105
Issue
1
Year of publication
1999
Pages
268 - 270
Database
ISI
SICI code
0007-1048(199904)105:1<268:MSWM5A>2.0.ZU;2-1
Abstract
A few cases of secondary neoplasms occurring after treatment with 2-chloro- 2'-deoxyadenosine (2CdA) have been reported, mostly in patients previously exposed to other anti-cancer drugs including alkylating agents (AA), Here w e report on the occurrence of a myelodysplastic syndrome (MDS) with monosom y 5 and/or 7 in two patients after 2CdA treatment, without or prior to othe r toxic exposure. In light of a literature review and given the involvement of chromosomes frequently abnormal in secondary leukaemias, we suggest tha t 2CdA may induce therapy-related MDS (t-MDS).