Three new quassinoid derivatives and related compounds as antitumor promoters from Brucea javanica

Authors
Rahman, S Fukamiya, N Tokuda, H Nishino, H Tagahara, K Lee, KH Okano, M
Citation
S. Rahman et al., Three new quassinoid derivatives and related compounds as antitumor promoters from Brucea javanica, B CHEM S J, 72(4), 1999, pp. 751-756
Citations number
20
Categorie Soggetti
Chemistry
Journal title
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
ISSN journal
00092673 → ACNP
Volume
72
Issue
4
Year of publication
1999
Pages
751 - 756
Database
ISI
SICI code
0009-2673(199904)72:4<751:TNQDAR>2.0.ZU;2-T
Abstract
Three new quassinoid derivatives [desmethyl-brusatol (1), desmethyl-brucean tinoside A (2), and butyl ester (3) of bruceoside D (6)] were isolated from the extract of Brucea javanica. Their structures were elucidated by spectr al evidence and chemical transformation to or from known compounds. The thr ee new quassinoid derivatives and related compounds have shown inhibitory e ffects against TPA-induced Epstein-Barr virus early antigen (EBV-EA) activa tion.